The specification of residual moisture is a crucial component of the regulatory filing for lyophilized drugs. Traditional moisture measurement methods such as Karl Fischer titration and gas chromatography are time-consuming and invasive when used for lyophilized products. Ideal measurements are rapid, require little or no sample preparation and are non-destructive. Near infrared (NIR) spectroscopy can be used to complement primary methods such as Karl Fischer titration, making moisture measurements faster and more reliable.
In this webinar, Desline Barber, Formulation Scientist at ProMetic BioTheraputics will present best practices for lyophilization and moisture measurement. Metrohm application scientists will then use case studies to demonstrate how sample throughput and productivity is increased when optimized KF titration measurements are simplified by NIR spectroscopy.