Many assay methods described in the United States Pharmacopeia and European Pharmacopoeia rely on the accuracy and simplicity of titration. These methods however, usually require several hundred milligrams of the active ingredient, which is expensive and difficult to obtain during the discovery and development stages. This analytical challenge is addressed by microtitration technology so that sample waste is minimized and re-analysis is avoided. Watch this webinar to hear Andy Lever, research scientist at AstraZeneca, discuss his experience optimizing titration for research and development.
Further optimization can come from selecting the proper solvent, optimizing titration parameters, and using alternative techniques such as thermometric titration. Lori Spafford, titration product manager at Metrohm USA, will discuss these elements of titration and offer practical insights for developing API microtitration methods.